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A Cellular Automaton Model as a First Model-Based Assessment of Interacting Mechanisms for Insulin Granule Transport in Beta Cells

ORCID
0000-0002-8008-4165
Affiliation
Institute of Dynamics and Vibrations, Technische Universität Braunschweig
Müller, Michael;
GND
1218570083
Affiliation
Institute of Dynamics and Vibrations, Technische Universität Braunschweig
Glombek, Mathias;
GND
1218569921
Affiliation
Institute of Dynamics and Vibrations, Technische Universität Braunschweig
Powitz, Jeldrick;
GND
1218569239
Affiliation
Institute of Pharmacology, Toxicology and Clinical Pharmacy
Brüning, Dennis;
ORCID
0000-0002-5218-3326
Affiliation
Institute of Pharmacology, Toxicology and Clinical Pharmacy
Rustenbeck, Ingo

In this paper a first model is derived and applied which describes the transport of insulin granules through the cell interior and at the membrane of a beta cell. A special role is assigned to the actin network, which significantly influences the transport. For this purpose, microscopically measured actin networks are characterized and then further ones are artificially generated. In a Cellular Automaton model, phenomenological laws for granule movement are formulated and implemented. Simulation results are compared with experiments, primarily using TIRF images and secretion rates. In this respect, good similarities are already apparent. The model is a first useful approach to describe complex granule transport processes in beta cells, and offers great potential for future extensions. Furthermore, the model can be used as a tool to validate hypotheses and associated mechanisms regarding their effect on exocytosis or other processes. For this purpose, the source code for the model is provided online.

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