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NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging in zebrafish

GND
1218047852
Affiliation/Institute
Institute of Microtechnology (IMT), Technische Universität Braunschweig
Mattern, Kai;
ORCID
0000-0003-4833-3771
Affiliation/Institute
Division of Cellular and Molecular Neurobiology, Zoological Institute, Technische Universität Braunschweig
Trotha, Jakob William von;
ORCID
0000-0003-4503-6392
Affiliation/Institute
Institute of Microtechnology (IMT), Technische Universität Braunschweig
Erfle, Peer;
ORCID
0000-0001-6593-8196
Affiliation/Institute
Division of Cellular and Molecular Neurobiology, Zoological Institute, Technische Universität Braunschweig
Köster, Reinhard Wolfgang;
ORCID
0000-0003-2090-6259
Affiliation/Institute
Institute of Microtechnology (IMT), Technische Universität Braunschweig
Dietzel, Andreas

While microfluidics enables chemical stimuli application with high spatio-temporal precision, light-sheet microscopy allows rapid imaging of entire zebrafish brains with cellular resolution. Both techniques, however, have not been combined to monitor whole-brain neural activity yet. Unlike conventional microfluidics, we report here an all-glass device (NeuroExaminer) that is compatible with whole-brain in vivo imaging using light-sheet microscopy and can thus provide insights into brain function in health and disease.

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