Continuous Krapcho Dealkoxycarbonylation in API Synthesis

Rehbein, Moritz C. ORCID; Husmann, Sascha; Wolters, J.; Priess, L.; Lechner, C.; Kunick, Conrad GND; Scholl, Stephan GND

A high pressure and high temperature continuous flow reactor has been used to intensify a Krapcho dealkoxycarbonylation reaction in the context of API synthesis. The reactor enables operation of the reaction above temperatures possible in batch and thus significantly increased conversion rates are achieved. Also a broader choice of solvents is possible by the use of the continuous process. Batch and continuous reaction are compared in terms of operation range and space-time-yield. Despite lower concentrations of the reactants in the continuous process, space-time-yield exceeds that of the batch process by more than an order of magnitude due to the higher reaction rates.

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Rehbein, Moritz / Husmann, Sascha / Wolters, J. / et al: Continuous Krapcho Dealkoxycarbonylation in API Synthesis. Braunschweig 2020.

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