Feedback

Continuous Krapcho Dealkoxycarbonylation in API Synthesis

Rehbein, Moritz C. ORCID; Husmann, Sascha; Wolters, J.; Priess, L.; Lechner, C.; Kunick, Conrad GND; Scholl, Stephan GND

A high pressure and high temperature continuous flow reactor has been used to intensify a Krapcho dealkoxycarbonylation reaction in the context of API synthesis. The reactor enables operation of the reaction above temperatures possible in batch and thus significantly increased conversion rates are achieved. Also a broader choice of solvents is possible by the use of the continuous process. Batch and continuous reaction are compared in terms of operation range and space-time-yield. Despite lower concentrations of the reactants in the continuous process, space-time-yield exceeds that of the batch process by more than an order of magnitude due to the higher reaction rates.

Cite

Citation style:
Rehbein, M.C., Husmann, S., Wolters, J., Priess, L., Lechner, C., Kunick, C., Scholl, S., 2020. Continuous Krapcho Dealkoxycarbonylation in API Synthesis. SPhERe Proceedings. https://doi.org/10.24355/dbbs.084-202001221355-0
Could not load citation form. Default citation form is displayed.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:

Rights

Use and reproduction:
All rights reserved

Export