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Accelerated Particle Separation in a DLD Device at Re > 1 Investigated by Means of µPIV.

ORCID
0000-0001-7304-8935
Affiliation
Institute for Microtechology, TU Braunschweig, 38124 Braunschweig, Germany.
Kottmeier, Jonathan;
GND
1206106727
Affiliation
Center of Pharmaceutical Engineering (PVZ), TU Braunschweig, 38106 Braunschweig, Germany.
Wullenweber, Maike;
Affiliation
Institute for Fluid Mechanics and Aerodynamics, TU Darmstadt, 64287 Darmstadt, Germany.
Blahout, Sebastian;
Affiliation
Institute for Fluid Mechanics and Aerodynamics, TU Darmstadt, 64287 Darmstadt, Germany.
Hussong, Jeanette;
GND
1157099688
Affiliation
Center of Pharmaceutical Engineering (PVZ), TU Braunschweig, 38106 Braunschweig, Germany.
Kampen, Ingo;
ORCID
0000-0002-6348-7309
Affiliation
Center of Pharmaceutical Engineering (PVZ), TU Braunschweig, 38106 Braunschweig, Germany.
Kwade, Arno;
ORCID
0000-0003-2090-6259
Affiliation
Institute for Microtechology, TU Braunschweig, 38124 Braunschweig, Germany.
Dietzel, Andreas

A pressure resistant and optically accessible deterministic lateral displacement (DLD) device was designed and microfabricated from silicon and glass for high-throughput fractionation of particles between 3.0 and 7.0 µm comprising array segments of varying tilt angles with a post size of 5 µm. The design was supported by computational fluid dynamic (CFD) simulations using OpenFOAM software. Simulations indicated a change in the critical particle diameter for fractionation at higher Reynolds numbers. This was experimentally confirmed by microparticle image velocimetry (µPIV) in the DLD device with tracer particles of 0.86 µm. At Reynolds numbers above 8 an asymmetric flow field pattern between posts could be observed. Furthermore, the new DLD device allowed successful fractionation of 2 µm and 5 µm fluorescent polystyrene particles at Re = 0.5-25.

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