Biochemistry of proinflammatory macrophage activation

Nonnenmacher, Yannic; Hiller, Karsten Peter Steffen GND

In the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic targets is being investigated as a means to treat infections and auto-immune diseases. In the present review, we will aim to provide an overview of the metabolic responses during proinflammatory macrophage activation and show how these changes modulate the immune response.

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Nonnenmacher, Yannic / Hiller, Karsten: Biochemistry of proinflammatory macrophage activation. 2018. Springer.

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